Innovation in Newcastle Disease Virus Vectored Avian Influenza Vaccines

Virus-Vectored Influenza Virus Vaccines

Despite the availability of an inactivated vaccine that has been licensed for >50 years, the influenza virus continues to cause morbidity and mortality worldwide. Constant evolution of circulating influenza virus strains and the emergence of new strains diminishes the effectiveness of annual vaccines that rely on a match with circulating influenza strains. Thus, there is a continued need for ne...

Vaccination of Chicks with Experimental Newcastle Disease and Avian Influenza Oilemulsion Vaccines by ln Ovo Inoculation

Newcastle disease virus-vectored vaccines expressing the hemagglutinin or neuraminidase protein of H5N1 highly pathogenic avian influenza virus protect against virus challenge in monkeys.

H5N1 highly pathogenic avian influenza virus (HPAIV) causes periodic outbreaks in humans, resulting in severe infections with a high (60%) incidence of mortality. The circulating strains have low human-to-human transmissibility; however, widespread concerns exist that enhanced transmission due to mutations could lead to a global pandemic. We previously engineered Newcastle disease virus (NDV), ...

Avian influenza and Newcastle disease.

Avian influenza (AI) and Newcastle disease (ND) affect various avian species, especially domestic poultry , and are caused by type A orthomyxoviruses and type 1 avian paramyxoviruses, respectively. 1,2 Clinical manifestations of such infections vary with the virus strain, the host species, and the presence or absence of secondary environmental factors or exacerbating agents. In domestic poultry...

Newcastle disease virus vectored vaccines as bivalent or antigen delivery vaccines

Recent advances in reverse genetics techniques make it possible to manipulate the genome of RNA viruses such as Newcastle disease virus (NDV). Several NDV vaccine strains have been used as vaccine vectors in poultry, mammals, and humans to express antigens of different pathogens. The safety, immunogenicity, and protective efficacy of these NDV-vectored vaccines have been evaluated in pre-clinic...